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首页> 外文OA文献 >The decrease of regulatory T cells correlates with excessive activation and apoptosis of CD8+ T cells in HIV-1-infected typical progressors, but not in long-term non-progressors
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The decrease of regulatory T cells correlates with excessive activation and apoptosis of CD8+ T cells in HIV-1-infected typical progressors, but not in long-term non-progressors

机译：调节性T细胞的减少与在HIV-1感染的典型进展者中CD8 + T细胞的过度活化和凋亡相关，而与长期非进展者无关

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Persistent HIV infection results in a decrease in absolute counts of CD4+ CD25+ regulatory T cells (Treg). To investigate the role of decreased Treg counts in the regulation of excessive activation and apoptosis of CD8+ T cells in human immunodeficiency virus (HIV)-1 infection, we characterized Treg in 83 HIV-1-infected individuals, including 19 long-term non-progressors (LTNPs) and 51 typical progressors (TPs) who were treatment-naïve, and 13 AIDS patients on highly active antiretroviral therapy (HAART), of whom nine were complete responders (CRs) and the remaining four were non-responders (NRs) to the treatment. TPs but not LTNPs had a significant decrease in absolute counts of circulating Treg, which was inversely correlated with the activation and apoptosis of CD8+ T cells. Efficient HAART was found to increase Treg counts in CR patients and temper the excessive activation and apoptosis of CD8+ T cells. Moreover, isolated Treg significantly inhibited the spontaneous and anti-CD3-induced apoptosis of CD8+ T cells in a dose-dependent manner in vitro. Thus, our findings indicate that the decrease in Treg closely correlates with the increase in apoptotic CD8+ T cells and disease progression in chronic HIV-1 infection, and that Treg may play a key role in maintaining the balance between the amount and quality of CD8+ T cells in HIV-1 infection. Manipulation of Treg function may be a promising strategy for immune therapy of this disease.
机译：持续的HIV感染导致CD4 + CD25 +调节性T细胞（Treg）的绝对计数减少。为了研究减少的Treg计数在人类免疫缺陷病毒（HIV）-1感染中CD8 + T细胞的过度激活和凋亡调控中的作用，我们对83名HIV-1感染者（包括19个长期非感染者）进行了Treg表征未进行过治疗的进展者（LTNPs）和51名典型进展者（TPs），以及13位接受高活性抗逆转录病毒疗法（HAART）的AIDS患者，其中9位是完全缓解者（CR），其余4位是无缓解者（NRs）去治疗。 TP而不是LTNP具有显着降低的循环Treg绝对计数，这与CD8 + T细胞的活化和凋亡成反比。发现有效的HAART可增加CR患者的Treg计数，并缓解CD8 + T细胞的过度活化和凋亡。此外，离体的Treg在体外以剂量依赖性方式显着抑制CD8 + T细胞的自发和抗CD3诱导的凋亡。因此，我们的研究结果表明，Treg的降低与慢性HIV-1感染中凋亡CD8 + T细胞的增加和疾病进展密切相关，并且Treg可能在维持CD8 + T的数量和质量之间的平衡中起关键作用HIV-1感染中的细胞。 Treg功能的操纵可能是对该疾病进行免疫治疗的有前途的策略。

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